The International PERForator ANeurysm Registry (PERFAN) - Natural History, Treatment, and Outcome of Intracranial Perforator Aneurysms
Team: Univ.-Prof. Dr. med. Elke Gizewski, MHBA; Dr. med. Malik Galijasevic, PhD
Cooperation: University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern (PI)

This international, multicenter, exploratory study aims to establish an international registry to address this knowledge gap. The goal is to gain insights into the diagnosis and treatment of these aneurysms. This would enable the definition of subgroups and specific risk factors for patients with perforator aneurysm who could benefit from treatment to prevent clinical  deterioration or rebleeding and ultimately improve patient care and outcomes.

Data evaluation from the nationwide Austrian Stroke Unit Registry covering consecutive stroke patients that had received EVT
Team: Univ.-Prof. Dr. med. Elke Gizewski, MHBA; Univ.-Prof. Dr. med. Astrid Grams, MBA
Cooperation: Austrian Stroke Units and Departments of Neuroradiology

Endovascular thrombectomy (EVT) has been previously found effective in acute stroke with large vessel occlusion (LVO) in patients with pre-morbid modified Rankin Score (mRS) <2. Based on the evidence from large multicentric RCTs EVT is recommended for a large group of patients with LVO. The work of this working group aim to analyze outcome parameters in real world settings.

Efficacy and safety of ThrombEctomy iN Stroke with extended leSION and extended time window: a randomized controlled trial (TENSION) study (EU H2020-SC1-2016-2017)
PI Austria: Univ.-Prof. Dr. med. Elke Gizewski, MHBA
Team: Univ.-Prof. Dr. med. Astrid Grams, MBA; Dr. med. univ. Florian Dazinger, MSc; Dr. med univ. Karin Gindlhuber; Assoz.-Prof. Dr. med. Bernhard Glodny
Cooperation: Departments of Neuroradiology and Neurology oft he University HospitalsmHamburg and Heidelberg (PI); Austria: Departments of Neuroradiology in Graz, Linz, Salzburg; Department of Neurology, Innsbruck (Prof. Dr. Michael Knoflach, Univ.-Prof. Dr. Stefan Kiechl)

In the TENSION trial, endovascular thrombectomy was associated with improved functional outcome and lower mortality at 90 days in patients with acute ischaemic stroke from large vessel occlusion with established large infarct. In a further secondary analyses we will study different long term effects, imaging biomarkers and specific outcome parameters.

Innsbruck secondary analysis: Metrics of cerebral arteries in relation to ASPECT score and outcome using an AI learning framework: A TENSION sub-analysis.
PIs: Univ.-Prof. Dr. med. Elke R. Gizewski., Prof.s Dr. Stefan Kiechl, Michael Knoflach, Dr. Mayer-Süß, Dr Lukas Neumann, Dr Stephanie Mangesius, PhD, Dipl.-Ing. M Tiefenthaler, BSc

The aim of this sub-analysis is to evaluate the feasibility and accuracy of vessel segmentation and vessel metric extraction including AI software. In particular it will be assessed whether vessel tortuosity (distance metric) interacts with the clinical outcome in stroke patients treated with thrombectomy.

Anaesthesiological care for thrombectomy in stroke (ACT in Stroke), DFG-supported project
Univ.-Prof. Dr. med. Elke Gizewski, MHBA, Univ.-Prof. Dr. med. Astrid Grams, MBA; Dr. med. univ. Florian Dazinger, MSc; Dr. med univ. Karin Gindlhuber; Assoz.-Prof. Dr. med. Bernhard Glodny; Dr. med. univ. Christian Siedentopf
Cooperation: Department of Anesthesiology, Department of Neurology; Departments of Anesthesiology, Neurology and Neuroradiology, Technical University of Munich (PI)

ACT in Stroke is a randomized multicenter trial, comparing the different anestheological care methods general anesthesia vs. stand-by during endovascular thrombectomy in ischemic stroke patients.